Avoid the usage of Promethazine with Codeine Oral Solution in patients with head damage, intracranial lesions, or possibly a pre-present rise in intracranial stress. In individuals who could be at risk of the intracranial effects of CO2 retention (e.

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Suggest sufferers to not enhance the dose or dosing frequency of Promethazine with Codeine Oral Solution for the reason that major adverse situations which include respiratory depression might happen with overdosage [see Warnings and Safeguards (5.

It really is soluble in drinking water and freely soluble in alcohol. The molecular weight is 320.88. Its molecular formulation is C17H20N2S•HCl, and it's got the subsequent chemical structure.

Focus–Adverse Reaction Associations There exists a romantic relationship in between growing codeine plasma focus and raising frequency of dose-similar opioid adverse reactions for example nausea, vomiting, CNS effects, and respiratory depression.

The respiratory despair involves a discount within the responsiveness from the Mind stem respiratory facilities to both improves in carbon dioxide tension and also to electrical stimulation.

Pregnancy Checks: Diagnostic pregnancy checks dependant on immunological reactions among HCG and anti-HCG could lead to Bogus-adverse or Bogus-optimistic interpretations.

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The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a bit soluble in Liquor. The molecular weight is 406.37. Its molecular click here formulation is C18H21NO3•H3PO4 • ½ H2O, and it has the next chemical composition.

If it is near to the time for the next dose, skip the skipped dose and go back to your standard time.

This craze indicates the benzene ring is most certainly involved in Digital functionality rather then hydrophobic interactions. The introduction of the oxaspiro ring para

Procedure of Overdose Treatment method of overdosage is pushed by the general scientific presentation, and includes discontinuation of Promethazine with Codeine Oral Solution jointly with establishment of suitable therapy. Give Major attention into the reestablishment of sufficient respiratory exchange by means of provision of the patent and protected airway as well as the institution of assisted or managed air flow.

Existence-threatening breathing issues (respiratory melancholy) . Promethazine with Codeine Oral Solution can cause breathing difficulties (respiratory melancholy) which will occur at any time all through treatment method and can result in death. Your danger of breathing complications is best when you 1st start out taking Promethazine with Codeine Oral Solution, are taking other medicines that could potentially cause breathing difficulties, have selected lung problems, are elderly or have particular other health conditions.

Prevent the use of Promethazine with Codeine Oral Solution in patients taking muscle mass relaxants. If concomitant use is necessary, keep an eye on sufferers for indications of respiratory depression Which may be bigger than in any other case anticipated.